Clodronate injection for bone health / Locomotion

For Horses

For the alleviation of clinical forelimb lameness associated with the bone resorptive processes of the distal sesamoid (navicular bone) in adult horses.

Active ingredient: Clodronic acid

Pack sizes: 51mg/ml solution for injection in 15ml glass vial.

Indications for use: Osphos® is an injectable bisphosphonate indicated for the control of clinical signs associated with navicular syndrome in horses 4 years and older. Osphos® is the only bisphosphonate approved by FDA for intramuscular use in horses.  Clodronate, the active ingredient in Osphos®, is a bisphosphonate that in laboratory animal studies and in vitro studies is known to inhibit bone resorption by reducing the number of active osteoclasts, regardless of the cause of osteoclast activity and it inhibits the formation and dissolution of calcium phosphate crystals in the bone matrix.

Dosage:  Administer 1.8mg/kg by intramuscular injection (IM) up to a maximum permissible dose of 900mg per horse. Divide the total volume evenly into three separate injection sites.

Storage:  Store below 25°C in a cool dry place. Discard any unused portion of the vial since Osphos® does not contain a preservative.